Second Lake   Be the first to submit input for Second Lake. If you have info on Second Lake, Leflore County, Mississippi please submit it here to improve this web site.          These outdoors activities are available near Second Lake.   Public Lands Near Second Lake: Holmes County State Park, Mississippi, 29 miles away   Hotels Near Second Lake: Budget Host Inn of Greenwood, Greenwood, 7 miles away Best Western Greenwood, Greenwood, 8 miles away Americas Best Value Inn and Suites Greenwood, Greenwood, 8 miles away Hampton Inn Greenwood, Greenwood, 8 miles away Comfort Suites Greenwood, Greenwood, 8 miles away